New Flea & Heartworm Prevention in One Tablet!
Trifexis
Trifexis is the most complete dog preventative monthly tablet veterinary medicine has ever seen!
Ever heard of it? The fabulous Comfortis (pronouced Come-FOR-tiss) flea pill for dogs combined with the safe and effective milbemycin= Trifexis(pronounced Try-fex-iss). Now you do not have to give Comfortis and a different heart worm prevention! You can just give one monthly product!
Did You Know?
Trifexis active ingredients are Spinosad and Milbemycin.
Trifexis is a once-a-month yummy flavored tablet for dogs that kills fleas and prevents heart worm infection. It also prevents and controls the intestinal worm infections: hookworms, roundworms, and whipworms.
Call All Pet Care Hospital and ask or mention the new flea and heart worm pill Trifexis at your next check-up to learn the ideal preventatives for your pet. You will save time and money!
Letter to Our Clients,
The most up to date, progressive parasite prevention products include Trifexis, Revolution feline, Advantage Multi, Advantix, Comfortis, Heartgard Plus, Interceptor & Preventic.
We have decided to phase out supplying the following: Advantage and Frontline.
In our attempts to better serve you, we occasionally find it necessary to re-evaluate which veterinary products best fit with our practice standards.
We would like to stress that the efficacy of these products was not a factor in this decision. Our goal in making this change is simply to improve our ability to provide you with the best service possible. Eliminating the above products will allow us to stay on top of new developments in veterinary medicine by making room for newer products as they come to market.
For those of you who wish to continue using these products, Advantage & Frontline are readily available over the counter at the large pet stores. We will happily approve prescriptions, just give us a call and we will help you set up your own online pharmacy account 877 DR TRULI
We apologize for any inconvenience this may cause however we believe that our decision will improve our ability to provide all of our clients with the most up to date progressive veterinary care.
Thank you,
Dr. Springer
Trifexis Warning
If your pet undergoes an off-label treatment, typically used for treatment of demodectic mange, with the drug ivermectin, you must not use spinosad, one of the active ingredients in Trifexis. Serious, and possibly deadly side-effects have been reported from the combination of spinosad and ivermectin.
Trifexis Reference
All Pet Care Hospitals Flea & Tick Page
Pharmaceutical Industry Today official news release
Note August 15, 2011:
Many people have been commenting on this website asking about their personal dogs. If you are not a registered client of Dr. Springer aka Doc Truli, we cannot answer medical questions regarding your pet. Please, please, call your family veterinarian for personal advice!

I’m wondering if anyone has reported dogs developing cysts after being on Trifexis for 2-3 months?
Both of my 2 young (2 yrs) Yorkie mix dogs have suddenly developed a cyst on their backs and I’m trying to determine why.
Two other foster dogs I have that are not on Trifexis do not have cysts.
What are the other ingredients in Trifexis? My dog has food allergies so I wanted to know what it is flavored with. Is it safe for dogs with food allergies?
my dogs currently take a heartworm prevention with ivermectin in it. How long do i need to wait before using Trifexis?
I was wondering if a side-effect of Trifexus is extremely dry, flakey, irritated skin? My newfoundland has been on the medication for a month now and within that month his skin has become very flakey. He tends to have skin issues, but has never had dry skin in the summer before. He is scratching himself also, so I am assuming the dryness is causing discomfort. He also has some redness on his tail. Could you tell me if this could be a side-effect from the Trifexsus?
My dogs pitbull mixes both young were given ivermectin and trifexis in the same month what would be symptoms and how long should i be watching for signs of a problem and how long would it take for it to cause a problem if it were going to ba a problem i am really scared for my babies so any information would be greatly appreciated
High dose ivermectin (like you would use for demodex) has been shown to cause seizures if given with Spinosad (ingredient in Trifexis and Comfortis.) It’s only some dogs, and the effect goes away when you stop the meds. If you are still giving the combo and see any tremors or seizures, contact your veterinarian right away for emergency care.
my vet prescribed me trifexis without testing for heartworms. ive heard you need to test before giving trifexis but my vet said no. im a little concerned about giving my dog trifexis now. i dont want anything fatal to happen if she does happen to have hearworms. what should i do?
My 8 month old yorkie has had 2 doses of trifexis and we just realized on the same day of each dose he has seizure like symptoms without the shaking and jerking. He is out of sorts, dazed, looks and acts like he is “high”. I’m not sure if this is a severe side effect of this medicine or he is really having a seizure. Can this be the trifexis and he needs to stop taking it?
Call your vet immediately! Yorkies also have portosystemic shunts and other problems that cause an unnatural, unhealthy “high.” It’s worth a call to the vet!
I have a 3 yr old border collie retriever mix. He currently is using frontline and heartgard without any problems other than the messy and drippy frontline. Would it be more trouble than its worth to switch to the trifexis? I like the idea of 1 pill per month doing the job of both the heartgard chewable and frontline drops, but I don’t want my baby to suffer any adverse effects. Any advice would be greatly appreciated. Oh and I heard somewhere that collies and other herding breeds had a bad reaction to the trifexis. Is there any truth to that? Thanks!
I have a 2 year old english bulldog who has been on advantix and interceptor. I now can not get interceptor because of a manufactoring hold or whatever the issue. I am thinking Trifexis would be a better option, #1 advantix gets everywhere (ie hands, furniture) since her hair is short and #2 i believe it is slighty cheaper than the 2 drugs. We are planning to breed her on her 4th heat which will be Sept 2012. I’ve read a study or 2 about using it that just say use caution. Ultimately, I know it is a question for my vet, but I was just wondering what your opnion about breeding and using trifexis is?
My 4 month old pitbull mix took Trifexis on June 18th. The vet recommended me take Ivermectin for demodex. She knows that he took Trifexis on the 18th, and recommended to start dosage of Ivermectin today (June 30th) with a starting dosage of .2ml. I spoke with a different vet over the phone and they said he should start Ivermectin on the 18th of July. I feel that’s too long to wait, because I don’t want his condition to get worse with Demodex. I don’t know if i should listen to a vet whom i talked over the phone, or the vet who physically saw my puppy. I’m also a little hesitant to have him take the Ivermectin because there was a second opinion. What should i do? He has an appointment to be seen in two weeks for re-weigh and dosage adjustments for Ivermectin.
One of our 10 month old American Pitbull puppies recently had what we were told was a toxic reaction to ivermectin due to an altered mdr gene. She had been taking ivermectin for a month and had gradually increased to the 1.8ml daily dose to be taken for 2-3 months. She was given her dose of ivermectin in the morning and was given her Trifexis with dinner. Later that evening she awoke suddenly and was experiencing constant seizures and could not walk or see. She was rushed to the emergency animal hospital where she was given iv valium overnight until the seizures stopped. She was released to us the next day and we took her to her doctor. We were told by both the emergency doctor and our regular veterinarian that it was not the Trifexis because these two drugs were different drugs for different conditions. We almost lost her due to their lack of knowledge of this drug combination. Thank you for making this information available online.
Hello, my dog has allergies so our vet started him on .2ml ivermectin orally monthly for heartworm prevention. Now she wants to switch him over to trifexis for the added flea prevention benefit. She said that he can start 30 days after his last dose of ivermectin. Is this alright? If not how long do we wait? Thank you for your time, I just worry about my boy!!
Mary
Can you tell me how long Trifexis stays in a dogs system? My vet has recommended ivermectin for my dogs mange, and I don’t want to start it too soon! Thank you!
I just called Novartis and asked this very question for a patient of mine. Your vet should call for you and answer that question.